Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50117957
Substrate
n/a
Meas. Tech.
ChEMBL_69125 (CHEMBL681467)
IC50
340±n/a nM
Citation
 Wright, SW; Carlo, AA; Carty, MD; Danley, DE; Hageman, DL; Karam, GA; Levy, CB; Mansour, MN; Mathiowetz, AM; McClure, LD; Nestor, NB; McPherson, RK; Pandit, J; Pustilnik, LR; Schulte, GK; Soeller, WC; Treadway, JL; Wang, IK; Bauer, PH Anilinoquinazoline inhibitors of fructose 1,6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography. J Med Chem 45:3865-77 (2002) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_RAT | Fbp | Fbp1 | Fructose-1,6-bisphosphatase
Type:
PROTEIN
Mol. Mass.:
39605.40
Organism:
Rattus norvegicus
Description:
ChEMBL_595158
Residue:
363
Sequence:
MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICDELF
  
Inhibitor
Name:
BDBM50117957
Synonyms:
CHEMBL123678 | {4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol
Type:
Small organic molecule
Emp. Form.:
C22H22N4O3S
Mol. Mass.:
422.5
SMILES:
CCOc1cc2ncnc(Nc3cccc(c3)-c3csc(CO)n3)c2cc1OCC
Structure:
Search PDB for entries with ligand similarity: