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Target
Bromodomain-containing protein 9
Ligand
BDBM50157607
Substrate
n/a
Meas. Tech.
ChEMBL_2068656 (CHEMBL4723909)
Kd
99±n/a nM
Citation
 Hügle, M; Regenass, P; Warstat, R; Hau, M; Schmidtkunz, K; Lucas, X; Wohlwend, D; Einsle, O; Jung, M; Breit, B; Günther, S 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J Med Chem 63:15603-15620 (2020) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 9
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 | Rhabdomyosarcoma antigen MU-RMS-40.8
Type:
PROTEIN
Mol. Mass.:
66994.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108000
Residue:
597
Sequence:
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
  
Inhibitor
Name:
BDBM50157607
Synonyms:
CHEMBL3753082 | US11773085, Compound B24
Type:
Small organic molecule
Emp. Form.:
C26H30ClN3O4S
Mol. Mass.:
516.052
SMILES:
CC(C)CS(=O)(=O)N[C@H]1CCC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc2c(C)cc(=O)n(C)c2c1 |r|
Structure:
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