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Target
Integrase
Ligand
BDBM50121971
Substrate
n/a
Meas. Tech.
ChEMBL_90864 (CHEMBL699299)
IC50
5000±n/a nM
Citation
 Neamati, N; Lin, Z; Karki, RG; Orr, A; Cowansage, K; Strumberg, D; Pais, GC; Voigt, JH; Nicklaus, MC; Winslow, HE; Zhao, H; Turpin, JA; Yi, J; Skalka, AM; Burke, TR; Pommier, Y Metal-dependent inhibition of HIV-1 integrase. J Med Chem 45:5661-70 (2002) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50121971
Synonyms:
2-Mercapto-benzoic acid N'-(2-mercapto-benzoyl)-hydrazide | CHEMBL157428 | bis(thiosalicyl)hydrazide
Type:
Small organic molecule
Emp. Form.:
C14H12N2O2S2
Mol. Mass.:
304.387
SMILES:
Sc1ccccc1C(=O)NNC(=O)c1ccccc1S
Structure:
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