Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50113590
Substrate
n/a
Meas. Tech.
ChEMBL_48982 (CHEMBL885073)
IC50
0.5±n/a nM
Citation
 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Wong, P; Huang, B; Tran, K; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Design and synthesis of factor Xa inhibitors and their prodrugs. Bioorg Med Chem Lett 13:297-300 (2002) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50113590
Synonyms:
(E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoic acid (3-bromo-2'-sulfamoyl-biphenyl-4-yl)-amide | (Z)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoic acid (3-bromo-2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL288232
Type:
Small organic molecule
Emp. Form.:
C23H20BrFN4O3S
Mol. Mass.:
531.397
SMILES:
C\C(=C(/F)C(=O)Nc1ccc(cc1Br)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Structure:
Search PDB for entries with ligand similarity: