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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50562615
Substrate
n/a
Meas. Tech.
ChEMBL_2079619 (CHEMBL4735410)
Ki
5.5±n/a nM
Citation
 Dreas, A; Kucwaj-Brysz, K; Pyziak, K; Kulesza, U; Wincza, E; Fabritius, CH; Michalik, K; Gabor-Worwa, E; Go?as, A; Milik, M; Masiejczyk, M; Majewska, E; Py?niak, K; Wójcik-Trechci?ska, U; Sandowska-Markiewicz, Z; Brzózka, K; Ostrowski, J; Rzymski, T; Mikula, M Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock. Eur J Med Chem 213:0 (2021) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50562615
Synonyms:
CHEMBL4764756
Type:
Small organic molecule
Emp. Form.:
C19H15ClN4O
Mol. Mass.:
350.802
SMILES:
Nc1n[nH]c2cc(ccc12)-c1ccc(=O)n(Cc2cccc(Cl)c2)c1
Structure:
Search PDB for entries with ligand similarity: