Reaction Details Report a problem with these data
Target
Casein kinase I isoform epsilon
Ligand
BDBM50364141
Substrate
n/a
Meas. Tech.
ChEMBL_2083577 (CHEMBL4739368)
IC50
7.7±n/a nM
Citation
 Grieco, I; Bissaro, M; Tiz, DB; Perez, DI; Perez, C; Martinez, A; Redenti, S; Mariotto, E; Bortolozzi, R; Viola, G; Cozza, G; Spalluto, G; Moro, S; Federico, S Developing novel classes of protein kinase CK1? inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems. Eur J Med Chem 216:0 (2021) [PubMed]  Article 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM50364141
Synonyms:
CHEMBL1951415
Type:
Small organic molecule
Emp. Form.:
C19H20FN5
Mol. Mass.:
337.394
SMILES:
Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: