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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50073099
Substrate
n/a
Meas. Tech.
ChEMBL_226200 (CHEMBL843326)
IC50
180±n/a nM
Citation
 Ikuina, Y; Amishiro, N; Miyata, M; Narumi, H; Ogawa, H; Akiyama, T; Shiotsu, Y; Akinaga, S; Murakata, C Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol. J Med Chem 46:2534-41 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC_RAT | Src | Tyrosine-protein kinase SRC | p60-Src | pp60c-src
Type:
PROTEIN
Mol. Mass.:
59976.76
Organism:
Rattus norvegicus
Description:
ChEMBL_453858
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGAFPASQTPSKPASADGHRGPNAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50073099
Synonyms:
(9E,11E)-(4R,6R,8R)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione | (9E,11E)-(4R,6S,8S)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(19),9,11,15,17-pentaene-2,13-dione | (9Z,11E)-(4R,6R,8R)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(19),9,11,15,17-pentaene-2,13-dione | (9Z,11E)-(4R,6R,8R)-17,19-Dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione | (9Z,11E)-(4S,6R,8S)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(19),9,11,15,17-pentaene-2,13-dione | (RA)/17-(allylamino)-17-demethoxygeldanamycin | (Z)-(R)-16-Chloro-17,19-dihydroxy-4-(R)-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(19),9,11,15,17-pentaene-2,13-dione | 16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0*6,8*]nonadeca-1(19),9,11,15,17-pentaene-2,13-dione | CHEMBL453386 | cid_16196977 | radicicol
Type:
Small organic molecule
Emp. Form.:
C18H17ClO6
Mol. Mass.:
364.777
SMILES:
C[C@H]1C[C@H]2O[C@H]2C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 |w:7.8,9.10|
Structure:
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