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Target
Outer membrane protein MIP
Ligand
BDBM50565510
Substrate
n/a
Meas. Tech.
ChEMBL_2092219 (CHEMBL4773482)
IC50
4900±n/a nM
Citation
 Scheuplein, NJ; Bzdyl, NM; Kibble, EA; Lohr, T; Holzgrabe, U; Sarkar-Tyson, M Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria. J Med Chem 63:13355-13388 (2020) [PubMed]  Article 
Target
Name:
Outer membrane protein MIP
Synonyms:
MIP_LEGPN | Macrophage infectivity potentiator | PPIase | Peptidyl-prolyl cis-trans isomerase | Rotamase | mip
Type:
PROTEIN
Mol. Mass.:
24869.94
Organism:
Legionella pneumophila
Description:
ChEMBL_701873
Residue:
233
Sequence:
MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
  
Inhibitor
Name:
BDBM50565510
Synonyms:
CHEMBL4794577
Type:
Small organic molecule
Emp. Form.:
C29H44N2O6
Mol. Mass.:
516.6695
SMILES:
C[C@H]1C[C@H](C)C(=O)C(C1)[C@H](O)CC1CC(=O)N(CC(=O)NC2C3CC4(C)CC(O)(C3)CC2(C)C4)C(=O)C1 |r,TLB:25:24:21:29.30.27,28:27:21:33.24.23,20:21:23:29.27.26,THB:26:27:21:33.24.23,26:24:21:29.30.27,32:31:23:29.27.26,20:21:29.30.27:33.24.23,30:31:23:29.27.26,30:27:21.31.33:23|
Structure:
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