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Target
Mucolipin-2
Ligand
BDBM50569848
Substrate
n/a
Meas. Tech.
ChEMBL_2110659 (CHEMBL4819509)
IC50
26800±n/a nM
Citation
 Leser, C; Keller, M; Gerndt, S; Urban, N; Chen, CC; Schaefer, M; Grimm, C; Bracher, F Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem 210:0 (2021) [PubMed]  Article 
Target
Name:
Mucolipin-2
Synonyms:
MCLN2_HUMAN | MCOLN2 | TRPML2 | Transient receptor potential channel mucolipin 2
Type:
PROTEIN
Mol. Mass.:
65947.37
Organism:
Homo sapiens
Description:
ChEMBL_120457
Residue:
566
Sequence:
MARQPYRFPQARIPERGSGVFRLTVRNAMAHRDSEMKEECLREDLKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECKDLNIFGSTQKNAQYVLVFDAFVIVICLASLILCTRSIVLALRLRKRFLNFFLEKYKRPVCDTDQWEFINGWYVLVIISDLMTIIGSILKMEIKAKNLTNYDLCSIFLGTSTLLVWVGVIRYLGYFQAYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFENLNTVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQNGFPETDLQEFLKECSSKEEYQKESSAFLSCICCRRRKRSDDHLIPIS
  
Inhibitor
Name:
BDBM50569848
Synonyms:
CHEMBL4858349
Type:
Small organic molecule
Emp. Form.:
C24H31N3O2
Mol. Mass.:
393.5218
SMILES:
COc1ccccc1N1CCN(CC1)[C@H]1CCCC[C@@H]1NC(=O)c1ccccc1 |r|
Structure:
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