Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 1
Ligand
BDBM50137352
Substrate
n/a
Meas. Tech.
ChEBML_105139
Ki
33000±n/a nM
Citation
 Hu, X; Zhu, J; Srivathsan, S; Pei, D Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors. Bioorg Med Chem Lett 14:77-9 (2003) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50137352
Synonyms:
(S)-2-Amino-hexanoic acid hydroxy-[(2-pyridin-2-yl-ethylcarbamoyl)-methyl]-amide | CHEMBL167633
Type:
Small organic molecule
Emp. Form.:
C15H24N4O3
Mol. Mass.:
308.3761
SMILES:
CCCC[C@H](N)C(=O)N(O)CC(=O)NCCc1ccccn1
Structure:
Search PDB for entries with ligand similarity: