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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50572739
Substrate
n/a
Meas. Tech.
ChEMBL_2117959 (CHEMBL4827025)
Kd
1220±n/a nM
Citation
 Huang, F; Zeng, Z; Zhang, W; Yan, Z; Chen, J; Yu, L; Yang, Q; Li, Y; Yu, H; Chen, J; Wu, C; Zhang, XK; Su, Y; Zhou, H Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPAR? with potential anti-diabetic efficacy. Eur J Med Chem 222:0 (2021) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50572739
Synonyms:
CHEMBL4864627
Type:
Small organic molecule
Emp. Form.:
C19H14ClFO2
Mol. Mass.:
328.765
SMILES:
CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1cccc(Cl)c1 |c:1|
Structure:
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