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Target
Kallikrein-6
Ligand
BDBM50574434
Substrate
n/a
Meas. Tech.
ChEMBL_2122486 (CHEMBL4831719)
IC50
1570±n/a nM
Citation
 Aït Amiri, S; Deboux, C; Soualmia, F; Chaaya, N; Louet, M; Duplus, E; Betuing, S; Nait Oumesmar, B; Masurier, N; El Amri, C Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation. J Med Chem 64:5667-5688 (2021) [PubMed]  Article 
Target
Name:
Kallikrein-6
Synonyms:
KLK6 | KLK6_HUMAN | Kallikrein 6 | PRSS18 | PRSS9
Type:
PROTEIN
Mol. Mass.:
26861.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_826901
Residue:
244
Sequence:
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
  
Inhibitor
Name:
BDBM50574434
Synonyms:
CHEMBL4861066
Type:
Small organic molecule
Emp. Form.:
C18H17ClN2O2
Mol. Mass.:
328.793
SMILES:
Cl.NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1
Structure:
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