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Target
Dual specificity mitogen-activated protein kinase kinase 3
Ligand
BDBM50141410
Substrate
n/a
Meas. Tech.
ChEBML_104056
IC50
>1000±n/a nM
Citation
 Wityak, J; Hobbs, FW; Gardner, DS; Santella, JB; Petraitis, JJ; Sun, JH; Favata, MF; Daulerio, AJ; Horiuchi, KY; Copeland, RA; Scherle, PA; Jaffe, BD; Trzaskos, JM; Magolda, RL; Trainor, GL; Duncia, JV Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors. Bioorg Med Chem Lett 14:1483-6 (2004) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 3
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPK/ERK kinase 3 (MEK3) | MAPKK 3 | MEK3 | MKK3 | MP2K3_HUMAN | PRKMK3 | SKK2
Type:
Protein
Mol. Mass.:
39321.50
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
347
Sequence:
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
  
Inhibitor
Name:
BDBM50141410
Synonyms:
(Z)-3-Amino-3-(2-amino-phenylsulfanyl)-2-[3-(hydroxy-pyridin-4-yl-methyl)-phenyl]-acrylonitrile | CHEMBL37493
Type:
Small organic molecule
Emp. Form.:
C21H18N4OS
Mol. Mass.:
374.459
SMILES:
Nc1ccccc1SC(=N)C(C#N)c1cccc(c1)C(O)c1ccncc1
Structure:
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