Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM15339
Substrate
n/a
Meas. Tech.
ChEMBL_2126308 (CHEMBL4835653)
IC50
20±n/a nM
Citation
Ahmed, SK; Haese, NN; Cowan, JT; Pathak, V; Moukha-Chafiq, O; Smith, VJ; Rodzinak, KJ; Ahmad, F; Zhang, S; Bonin, KM; Streblow, AD; Streblow, CE; Kreklywich, CN; Morrison, C; Sarkar, S; Moorman, N; Sander, W; Allen, R; DeFilippis, V; Tekwani, BL; Wu, M; Hirsch, AJ; Smith, JL; Tower, NA; Rasmussen, L; Bostwick, R; Maddry, JA; Ananthan, S; Gerdes, JM; Augelli-Szafran, CE; Suto, MJ; Morrison, TE; Heise, MT; Streblow, DN; Pathak, AK Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem 64:4762-4786 (2021) [PubMed] Article
More Info.:
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Inhibitor
Name:
BDBM15339
Synonyms:
6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid | 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid | Biphenquinate | Brequinar | US20240034730, Compound Brequinar
Type:
Small organic molecule
Emp. Form.:
C23H15F2NO2
Mol. Mass.:
375.3675
SMILES:
Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F