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Target
cGMP-dependent protein kinase 1
Ligand
BDBM50576759
Substrate
n/a
Meas. Tech.
ChEMBL_2127761 (CHEMBL4837106)
EC50
8800±n/a nM
Citation
 Hanisak, J; Soriano, A; Adam, GC; Basso, A; Bauman, D; Bell, D; Frank, E; O'Donnell, G; Tawa, P; Verras, A; Yu, Y; Zhang, L; Seganish, WM Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 ? (PKG1?). ACS Med Chem Lett 12:1275-1282 (2021) [PubMed]  Article 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
GMP-dependent protein kinase I | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | Protein Kinase G | cGMP-dependent protein kinase | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase 1 beta
Type:
Protein
Mol. Mass.:
76358.04
Organism:
Homo sapiens (Human)
Description:
Q13976
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM50576759
Synonyms:
CHEMBL4856290
Type:
Small organic molecule
Emp. Form.:
C23H25Cl2N3O2
Mol. Mass.:
446.37
SMILES:
OC[C@@H](O[C@H]1CCCN(Cc2ncc[nH]2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 |r|
Structure:
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