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Target
Alternative oxidase, mitochondrial
Ligand
BDBM50576971
Substrate
n/a
Meas. Tech.
ChEMBL_2128589 (CHEMBL4838018)
IC50
360±n/a nM
Citation
 Cueto-Díaz, EJ; Ebiloma, GU; Alfayez, IA; Ungogo, MA; Lemgruber, L; González-García, MC; Giron, MD; Salto, R; Fueyo-González, FJ; Shiba, T; González-Vera, JA; Ruedas Rama, MJ; Orte, A; de Koning, HP; Dardonville, C Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase. Eur J Med Chem 220:0 (2021) [PubMed]  Article 
Target
Name:
Alternative oxidase, mitochondrial
Synonyms:
1.-.-.- | AOX | AOX_TRYBB | Alternative oxidase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
37603.97
Organism:
Trypanosoma brucei brucei
Description:
ChEMBL_117839
Residue:
329
Sequence:
MFRNHASRITAAAAPWVLRTACRQKSDAKTPVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKNPEEMYSNQPSGKTRTDFGSEGAKTASNVNKHV
  
Inhibitor
Name:
BDBM50576971
Synonyms:
CHEMBL4846979
Type:
Small organic molecule
Emp. Form.:
C41H55BrN2O5
Mol. Mass.:
735.79
SMILES:
[Br-].Cc1cc(O)cc(O)c1C(=O)OCCCCCCCCCCCCCC[n+]1ccc(\C=C\c2cc3CCCN4CCCc(c2O)c34)cc1
Structure:
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