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Target
Alternative oxidase, mitochondrial
Ligand
BDBM50576980
Substrate
n/a
Meas. Tech.
ChEMBL_2128589 (CHEMBL4838018)
IC50
1800±n/a nM
Citation
 Cueto-Díaz, EJ; Ebiloma, GU; Alfayez, IA; Ungogo, MA; Lemgruber, L; González-García, MC; Giron, MD; Salto, R; Fueyo-González, FJ; Shiba, T; González-Vera, JA; Ruedas Rama, MJ; Orte, A; de Koning, HP; Dardonville, C Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase. Eur J Med Chem 220:0 (2021) [PubMed]  Article 
Target
Name:
Alternative oxidase, mitochondrial
Synonyms:
1.-.-.- | AOX | AOX_TRYBB | Alternative oxidase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
37603.97
Organism:
Trypanosoma brucei brucei
Description:
ChEMBL_117839
Residue:
329
Sequence:
MFRNHASRITAAAAPWVLRTACRQKSDAKTPVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKNPEEMYSNQPSGKTRTDFGSEGAKTASNVNKHV
  
Inhibitor
Name:
BDBM50576980
Synonyms:
CHEMBL4846671
Type:
Small organic molecule
Emp. Form.:
C28H42BrNO4
Mol. Mass.:
536.541
SMILES:
[Br-].Cc1cc[n+](CCCCCCCCCCCCCCOc2cc(C)c(C(O)=O)c(O)c2)cc1
Structure:
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