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Target
Histone deacetylase 8
Ligand
BDBM50397360
Substrate
n/a
Meas. Tech.
ChEMBL_2134345 (CHEMBL4843955)
IC50
10.0±n/a nM
Citation
 Ghazy, E; Heimburg, T; Lancelot, J; Zeyen, P; Schmidtkunz, K; Truhn, A; Darwish, S; Simoben, CV; Shaik, TB; Erdmann, F; Schmidt, M; Robaa, D; Romier, C; Jung, M; Pierce, R; Sippl, W Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. Eur J Med Chem 225:0 (2021) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50397360
Synonyms:
CHEMBL2170177 | US10188756, Compound CN110
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3
Mol. Mass.:
296.3205
SMILES:
COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1
Structure:
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