Target
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM50579514
Substrate
n/a
Meas. Tech.
ChEMBL_2135439 (CHEMBL4845049)
IC50
270±n/a nM
Citation
 Turdi, HChao, HHangeland, JJAhmad, SMeng, WBrigance, RZhao, GWang, WMoore, FYe, XYMathur, AHou, XKempson, JWu, DRLi, YXAzzara, AVMa, ZChu, CHChen, LCullen, MJRooney, SHarvey, SKopcho, LPanemangelor, RAbell, LO'Malley, KKeim, WJDierks, EChang, SFoster, KApedo, AHarden, DDabros, MGao, QPelleymounter, MAWhaley, JMRobl, JACheng, DLawrence, RMDevasthale, P Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem 64:14773-14792 (2021) [PubMed]  Article 
Target
Name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2_MOUSE | Mannoside acetylglucosaminyltransferase 2 | Mgat2 | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Type:
PROTEIN
Mol. Mass.:
51045.37
Organism:
Mus musculus
Description:
ChEMBL_107583
Residue:
442
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKSDALGPPLLDAEPVRGAGHLAVSVGIRRVSNESAAPLVPAVPRPEVDNLTLRYRSLVYQLNFDQMLRNVGNDGTWSPGELVLVVQVHNRPEYLRLLIDSLRKAQGIQEVLVIFSHDFWSAEINSLISRVDFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLKKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLQDYTGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTLACLPKIWKVLVPQAPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYLFPETLVIGEKFPMAAISPPRKNGGWGDIRDHELCKSYRRLQ
  
Inhibitor
Name:
BDBM50579514
Synonyms:
CHEMBL4863703
Type:
Small organic molecule
Emp. Form.:
C25H24F6N2O3
Mol. Mass.:
514.4601
SMILES:
CNC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F)c1ccc(C)cc1 |r,t:4|
Structure:
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