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Target
Histone deacetylase 1
Ligand
BDBM50135752
Substrate
n/a
Meas. Tech.
ChEMBL_87866 (CHEMBL857175)
IC50
513±n/a nM
Citation
 Wang, DF; Wiest, O; Helquist, P; Lan-Hargest, HY; Wiech, NL On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors. J Med Chem 47:3409-17 (2004) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
HD1 | HDAC1_MOUSE | Hdac1 | Histone deacetylase 1/2
Type:
Protein
Mol. Mass.:
55062.26
Organism:
Mus musculus (Mouse)
Description:
O09106
Residue:
482
Sequence:
MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50135752
Synonyms:
(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide | (E)-N-Hydroxy-3-(1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide | CHEMBL12760 | N-Hydroxy-3-((E)-1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide | N-Hydroxy-3-(1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3
Mol. Mass.:
284.3098
SMILES:
Cn1cc(cc1C=CC(=O)NO)C(=O)Cc1ccccc1 |w:7.8|
Structure:
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