Reaction Details Report a problem with these data
Target
Interleukin-17A
Ligand
BDBM50581141
Substrate
n/a
Meas. Tech.
ChEMBL_2149819 (CHEMBL5034281)
IC50
<100±n/a nM
Citation
 Ko?trun, S; Fajdeti?, A; Pe?i?, D; Braj?a, K; Benceti? Mihaljevi?, V; Jeli?, D; Petrini? Grba, A; Elenkov, I; Rup?i?, R; Kapi?, S; Ozimec Landek, I; Butkovi?, K; Grgi?evi?, A; ?iher, D; ?iko?, A; Padovan, J; Saxty, G; Dack, K; Bladh, H; Skak-Nielsen, T; Feldbaek Nielsen, S; Lambert, M; Stahlhut, M Macrolide Inspired Macrocycles as Modulators of the IL-17A/IL-17RA Interaction. J Med Chem 64:8354-8383 (2021) [PubMed]  Article 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM50581141
Synonyms:
CHEMBL5075374
Type:
Small organic molecule
Emp. Form.:
C38H43ClF2N4O4
Mol. Mass.:
693.222
SMILES:
FC(F)(C(=O)N[C@@H](Cc1ccccc1Cl)C(=O)Nc1ccc(CCNC(=O)CC2(CC(=O)N3CCCC3)CCCC2)cc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: