Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50150362
Substrate
n/a
Meas. Tech.
ChEMBL_305746 (CHEMBL829418)
IC50
5100±n/a nM
Citation
 Gopalsamy, A; Lim, K; Ellingboe, JW; Krishnamurthy, G; Orlowski, M; Feld, B; van Zeijl, M; Howe, AY Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase. Bioorg Med Chem Lett 14:4221-4 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50150362
Synonyms:
CHEMBL310098 | [(2-Chloro-6-methoxy-5-trifluoromethyl-naphthalene-1-carbonyl)-methyl-amino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C16H13ClF3NO4
Mol. Mass.:
375.727
SMILES:
COc1ccc2c(C(=O)N(C)CC(O)=O)c(Cl)ccc2c1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: