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Target
Cholesterol 24-hydroxylase
Ligand
BDBM50583516
Substrate
n/a
Meas. Tech.
ChEMBL_2157566 (CHEMBL5042226)
IC50
65±n/a nM
Citation
 Kajita, Y; Ikeda, S; Yoshikawa, M; Fukuda, H; Watanabe, E; Yano, J; Lane, W; Miyamoto, M; Ishii, T; Nishi, T; Koike, T Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J Med Chem 65:3343-3358 (2022) [PubMed]  Article 
Target
Name:
Cholesterol 24-hydroxylase
Synonyms:
CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H)
Type:
Protein
Mol. Mass.:
56834.45
Organism:
Homo sapiens (Human)
Description:
Q9Y6A2
Residue:
500
Sequence:
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
  
Inhibitor
Name:
BDBM50583516
Synonyms:
CHEMBL5082660
Type:
Small organic molecule
Emp. Form.:
C17H20F3N5O
Mol. Mass.:
367.3688
SMILES:
CN(C)C(=O)C1CCN(CC1)c1cnccc1-n1cc(cn1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: