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Target
DCN1-like protein 3
Ligand
BDBM50525313
Substrate
n/a
Meas. Tech.
ChEMBL_2159069 (CHEMBL5043819)
Ki
591720±n/a nM
Citation
 He, ZX; An, Q; Wei, B; Zhou, WJ; Wei, BF; Gong, YP; Zhang, X; Gao, G; Dong, GJ; Huo, JL; Zhang, XH; Yang, FF; Liu, HM; Ma, LY; Zhao, W Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem 65:163-190 (2022) [PubMed]  Article 
Target
Name:
DCN1-like protein 3
Synonyms:
DCN1-like protein 3 | DCNL3 | DCNL3_HUMAN | DCUN1 domain-containing protein 3 | DCUN1D3 | Defective in cullin neddylation protein 1-like protein 3 | SCCRO3 | Squamous cell carcinoma-related oncogene 3 | Synonyms=SCCRO3
Type:
PROTEIN
Mol. Mass.:
34281.38
Organism:
Homo sapiens
Description:
ChEMBL_118139
Residue:
304
Sequence:
MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT
  
Inhibitor
Name:
BDBM50525313
Synonyms:
CHEMBL4592844
Type:
Small organic molecule
Emp. Form.:
C18H12N4S3
Mol. Mass.:
380.51
SMILES:
Cc1ccc(cc1)-c1nc(SCC#C)nc(Sc2nccs2)c1C#N
Structure:
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