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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50584357
Substrate
n/a
Meas. Tech.
ChEMBL_2159559 (CHEMBL5044309)
IC50
15±n/a nM
Citation
 Chen, L; Su, M; Wu, XZ; Wang, DZ; Kang, YY; Wang, CG; Assani, I; Wang, MX; Zhao, SF; Lv, SM; Wang, JW; Sun, B; Li, Y; Jin, Q; Huang, RZ; Liao, ZX Discovery of 2H-chromone-4-one based sulfonamide derivatives as potent retinoic acid receptor-related orphan receptor ?t inverse agonists. Eur J Med Chem 229:0 (2022) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50584357
Synonyms:
CHEMBL5084316
Type:
Small organic molecule
Emp. Form.:
C26H33NO5S
Mol. Mass.:
471.609
SMILES:
CC(C)CN(c1ccc(C)cc1C)S(=O)(=O)c1ccc2OC(CC(=O)c2c1)C1CCOCC1
Structure:
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