Reaction Details Report a problem with these data
Target
GTPase KRas
Ligand
BDBM50586344
Substrate
n/a
Meas. Tech.
ChEMBL_2165963 (CHEMBL5050824)
EC50
6.6±n/a nM
Citation
 Kargbo, RB Small-Molecule Inhibitor of the Oncogenic KRAS ACS Med Chem Lett 13:767-769 (2022) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50586344
Synonyms:
CHEMBL5073894
Type:
Small organic molecule
Emp. Form.:
C30H38F4N6O2
Mol. Mass.:
590.6553
SMILES:
C[C@@H]1Cc2c(C[C@H]1c1c(F)c(N)ccc1C(F)(F)F)nc(OC[C@@H]1CCCN1C)nc2N1CCN(C[C@@H]1C)C(=O)C=C |r|
Structure:
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