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Target
Stimulator of interferon genes protein
Ligand
BDBM50509049
Substrate
n/a
Meas. Tech.
ChEMBL_2203818 (CHEMBL5116526)
Kd
1.6±n/a nM
Citation
 Niu, J; Bai, H; Li, Z; Gao, Y; Zhang, Y; Wang, X; Yang, Y; Xu, Y; Geng, M; Xie, Z; Zhou, B Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50509049
Synonyms:
CHEMBL4440744
Type:
Small organic molecule
Emp. Form.:
C34H38N12O4
Mol. Mass.:
678.7435
SMILES:
CCn1nc(C)cc1C(=O)\N=c1/[nH]c2cc(ccc2n1CCCCn1c2ccc(cc2[nH]\c1=N/C(=O)c1cc(C)nn1CC)C(N)=O)C(N)=O
Structure:
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