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Target
Potassium voltage-gated channel subfamily KQT member 4
Ligand
BDBM50592360
Substrate
n/a
Meas. Tech.
ChEMBL_2203875 (CHEMBL5116583)
EC50
660±n/a nM
Citation
 Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype. Bioorg Med Chem Lett 71:0 (2022) [PubMed] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 4
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4
Type:
PROTEIN
Mol. Mass.:
77131.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1520985
Residue:
695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
  
Inhibitor
Name:
BDBM50592360
Synonyms:
CHEMBL4549229
Type:
Small organic molecule
Emp. Form.:
C16H16F4N4O2
Mol. Mass.:
372.3175
SMILES:
CCOC(=O)Nc1ccc(NCc2ccc(nc2)C(F)(F)F)c(F)c1N
Structure:
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