Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM50594478
Substrate
n/a
Meas. Tech.
ChEMBL_2213082 (CHEMBL5126031)
EC50
0.250000±n/a nM
Citation
 Sabnis, RW Novel Macrocyclic Urea Orexin Receptor Agonists for Treating Sleep Disorders. ACS Med Chem Lett 13:1010-1011 (2022) [PubMed] 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50594478
Synonyms:
CHEMBL5176663
Type:
Small organic molecule
Emp. Form.:
C26H34F2N6O4
Mol. Mass.:
532.5828
SMILES:
CCN1[C@H](C)c2cc(c(OC)cn2)-c2cc3ccnn3c(OCCOCC[C@H](CCC(C)(F)F)NC1=O)n2 |r|
Structure:
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