Reaction Details Report a problem with these data
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Ligand
BDBM130503
Substrate
n/a
Meas. Tech.
ChEMBL_2214948 (CHEMBL5128080)
IC50
55±n/a nM
Citation
 Xi, M; Sun, T; Chai, S; Xie, M; Chen, S; Deng, L; Du, K; Shen, R; Sun, H Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease. Eur J Med Chem 232:0 (2022) [PubMed] 
Target
Name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:
3.1.4.35 | PDE9A_MOUSE | Pde8b | Pde9a
Type:
PROTEIN
Mol. Mass.:
61629.34
Organism:
Mus musculus
Description:
ChEMBL_120641
Residue:
534
Sequence:
MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELIQGVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRNNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLWESREHYEELKQLDDAMKELQKKTESLTSGAPENTTEKNRDAKDSEGHSPPN
  
Inhibitor
Name:
BDBM130503
Synonyms:
US8822479, 37-1
Type:
Small organic molecule
Emp. Form.:
C15H12ClF3N4O
Mol. Mass.:
356.73
SMILES:
CC(Cc1nc2n(ncc2c(=O)[nH]1)-c1ccccc1Cl)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: