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Target
Probable G-protein coupled receptor 88
Ligand
BDBM50595993
Substrate
n/a
Meas. Tech.
ChEMBL_2218766 (CHEMBL5132100)
EC50
14±n/a nM
Citation
 Rahman, MT; Decker, AM; Laudermilk, L; Maitra, R; Ma, W; Ben Hamida, S; Darcq, E; Kieffer, BL; Jin, C Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies. J Med Chem 64:12397-12413 (2021) [PubMed] 
Target
Name:
Probable G-protein coupled receptor 88
Synonyms:
GPR88 | GPR88_HUMAN | Probable G-protein coupled receptor 88 | STRG | Striatum-specific G-protein coupled receptor
Type:
PROTEIN
Mol. Mass.:
40264.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109566
Residue:
384
Sequence:
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
  
Inhibitor
Name:
BDBM50595993
Synonyms:
CHEMBL5175064
Type:
Small organic molecule
Emp. Form.:
C27H35N5O3
Mol. Mass.:
477.5985
SMILES:
CCC[C@H](C)COc1ccc(cc1)[C@H](Cn1cc(nn1)C(=O)NC)NC(=O)[C@@H](C)c1ccccc1 |r|
Structure:
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