Reaction Details Report a problem with these data
Target
Reverse transcriptase/RNaseH
Ligand
BDBM50172748
Substrate
n/a
Meas. Tech.
ChEMBL_321416 (CHEMBL881947)
IC50
2500±n/a nM
Citation
Bedoya, LM; Beltrán, M; Sancho, R; Olmedo, DA; Sánchez-Palomino, S; del Olmo, E; López-Pérez, JL; Muñoz, E; San Feliciano, A; Alcamí, J 4-Phenylcoumarins as HIV transcription inhibitors. Bioorg Med Chem Lett 15:4447-50 (2005) [PubMed] Article
More Info.:
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
Inhibitor
Name:
BDBM50172748
Synonyms:
2,7-Dihydroxy-6-isobutyryl-8-(3-methyl-but-2-enyl)-4-phenyl-chromen-5-one | 5,7-Dihydroxy-6-isobutyryl-8-(3-methyl-but-2-enyl)-4-phenyl-chromen-2-one | CHEMBL197069 | mesuol
Type:
Small organic molecule
Emp. Form.:
C24H24O5
Mol. Mass.:
392.4444
SMILES:
[#6]-[#6](-[#6])-[#6](=O)-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c2oc(=O)cc(-c3ccccc3)c2c1-[#8]