Reaction Details Report a problem with these data
Target
Ceramide glucosyltransferase
Ligand
BDBM50597261
Substrate
n/a
Meas. Tech.
ChEMBL_2223201 (CHEMBL5136535)
EC50
0.021000±n/a nM
Citation
 Sabnis, RW Modified Benzofuran-carboxamide Compounds as Glucosylceramide Synthase Inhibitors for Treating Diseases. ACS Med Chem Lett 13:879-880 (2022) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM50597261
Synonyms:
CHEMBL5170109 | US20230391758, Compound 21
Type:
Small organic molecule
Emp. Form.:
C26H30N2O3
Mol. Mass.:
418.528
SMILES:
CCCCOc1ccccc1-c1cccc2cc(oc12)C(=O)NC1CN2CCC1CC2 |THB:22:23:26.27:30.29,(9.53,-1.89,;8.2,-2.66,;6.86,-1.89,;5.53,-2.66,;4.2,-1.89,;2.86,-2.66,;2.86,-4.2,;1.53,-4.97,;.2,-4.21,;.19,-2.67,;1.53,-1.89,;1.53,-.35,;2.85,.42,;2.85,1.96,;1.52,2.72,;.19,1.95,;-1.28,2.43,;-2.19,1.18,;-1.28,-.07,;.19,.41,;-3.73,1.18,;-4.5,-.15,;-4.53,2.55,;-6.07,2.55,;-6.95,1.64,;-8.12,2.54,;-9.53,2.31,;-8.74,3.49,;-7.12,3.57,;-6.49,4.97,;-7.68,4.18,)|
Structure:
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