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Target
Programmed cell death protein 4
Ligand
BDBM50598483
Substrate
n/a
Meas. Tech.
ChEMBL_2227009 (CHEMBL5140522)
EC50
2251±n/a nM
Citation
 Peng, T; He, Y; Wang, T; Yu, J; Ma, X; Zhou, Z; Sheng, Y; Li, L; Peng, H; Li, S; Zou, J; Yuan, Y; Zhao, Y; Shi, H; Li, F; Liu, W; Hu, K; Lu, X; Zhang, G; Wang, F Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem 65:11010-11033 (2022) [PubMed] 
Target
Name:
Programmed cell death protein 4
Synonyms:
H731 | Neoplastic transformation inhibitor protein | Nuclear antigen H731-like | PDCD4 | PDCD4_HUMAN | Protein 197/15a
Type:
PROTEIN
Mol. Mass.:
51720.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_776474
Residue:
469
Sequence:
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
  
Inhibitor
Name:
BDBM50598483
Synonyms:
CHEMBL5170759
Type:
Small organic molecule
Emp. Form.:
C14H15NO4
Mol. Mass.:
261.2732
SMILES:
CCOC(=O)c1nc(oc1C)-c1ccc(OC)cc1
Structure:
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