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Target
Lysine-specific demethylase 4E
Ligand
BDBM79334
Substrate
n/a
Meas. Tech.
ChEMBL_2227651 (CHEMBL5141164)
IC50
920±n/a nM
Citation
 Wu, Q; Young, B; Wang, Y; Davidoff, AM; Rankovic, Z; Yang, J Recent Advances with KDM4 Inhibitors and Potential Applications. J Med Chem 65:9564-9579 (2022) [PubMed] 
Target
Name:
Lysine-specific demethylase 4E
Synonyms:
2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E)
Type:
Enzyme
Mol. Mass.:
56815.71
Organism:
Homo sapiens (Human)
Description:
B2RXH2
Residue:
506
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL
  
Inhibitor
Name:
BDBM79334
Synonyms:
MLS002391556 | N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide;2,2,2-trifluoroacetic acid | N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolyl)benzamide;2,2,2-trifluoroacetic acid | N-[3-(dimethylamino)propyl]-4-(8-hydroxyquinolin-6-yl)benzamide;2,2,2-trifluoroacetic acid | N-[3-(dimethylamino)propyl]-4-(8-oxidanylquinolin-6-yl)benzamide;2,2,2-tris(fluoranyl)ethanoic acid | SMR001355524 | cid_44143208
Type:
Small organic molecule
Emp. Form.:
C21H23N3O2
Mol. Mass.:
349.4262
SMILES:
CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(O)c2ncccc2c1
Structure:
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