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Target
G-protein coupled receptor 84
Ligand
BDBM50599099
Substrate
n/a
Meas. Tech.
ChEMBL_2228897 (CHEMBL5142410)
IC50
17±n/a nM
Citation
 Mahindra, A; Jenkins, L; Marsango, S; Huggett, M; Huggett, M; Robinson, L; Gillespie, J; Rajamanickam, M; Morrison, A; McElroy, S; Tikhonova, IG; Milligan, G; Jamieson, AG Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. J Med Chem 65:11270-11290 (2022) [PubMed] 
Target
Name:
G-protein coupled receptor 84
Synonyms:
EX33 | G-protein coupled receptor 84 | GPR84 | GPR84_HUMAN | Inflammation-related G-protein coupled receptor EX33
Type:
PROTEIN
Mol. Mass.:
43726.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116040
Residue:
396
Sequence:
MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
  
Inhibitor
Name:
BDBM50599099
Synonyms:
CHEMBL5191540
Type:
Small organic molecule
Emp. Form.:
C25H20N4O
Mol. Mass.:
392.4525
SMILES:
OCc1ccc(cc1)-c1nnc(Cc2c[nH]c3ccccc23)nc1-c1ccccc1
Structure:
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