Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase subunit beta-1
Ligand
BDBM50600527
Substrate
n/a
Meas. Tech.
ChEMBL_2234478 (CHEMBL5148250)
EC50
800±n/a nM
Citation
 Tamura, Y; Morita, I; Hinata, Y; Kojima, E; Ozasa, H; Ikemoto, H; Asano, M; Wada, T; Hayasaki-Kajiwara, Y; Iwasaki, T; Matsumura, K Identification of novel indole derivatives as highly potent AMPK activators with anti-diabetic profiles. Bioorg Med Chem Lett 68:0 (2022) [PubMed] 
Target
Name:
5'-AMP-activated protein kinase subunit beta-1
Synonyms:
AAKB1_RAT | AMPK subunit beta-1 | AMPKb | Prkab1
Type:
PROTEIN
Mol. Mass.:
30391.98
Organism:
Rattus norvegicus
Description:
ChEMBL_117047
Residue:
270
Sequence:
MGNTSSERAALERQAGHKTPRRDSSGGTKDGDRPKILMDSPEDADIFHTEEMKAPEKEEFLAWQHDLEVNEKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM50600527
Synonyms:
CHEMBL5201587
Type:
Small organic molecule
Emp. Form.:
C20H14N2O3S
Mol. Mass.:
362.402
SMILES:
OC1=C(C#N)C(=O)NC2SC=C(C12)c1ccc(cc1)-c1ccccc1O |c:1,10|
Structure:
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