Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit beta
Ligand
BDBM50179896
Substrate
n/a
Meas. Tech.
ChEMBL_339397 (CHEMBL866053)
IC50
83±n/a nM
Citation
 Meegalla, SK; Doller, D; Liu, R; Sha, D; Lee, Y; Soll, RM; Wisnewski, N; Silver, GM; Dhanoa, D Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles. Bioorg Med Chem Lett 16:1702-6 (2006) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit beta
Synonyms:
GABA receptor subunit | GBRB_MUSDO | Rdl
Type:
PROTEIN
Mol. Mass.:
63660.23
Organism:
Musca domestica
Description:
ChEMBL_339397
Residue:
576
Sequence:
MSDSMLYQTLQTCLPKSRLITLWLAFTLAMLIQEPRRHAATVNAATAGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYKWNEGPNSVGVSSEVSLPQFKVLGHRQRAVEISLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVVISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMTIQKMAEQKKQQQLDGVQPPPNPNPNTMVDHGGHGHGHGHHSHGHPHVPKQTVSNRPIGFQTMQQQNIGGRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPPVGPHGPGPQGPPGGPPAGGGGGGAPPEGGDAEAAVPAHLLHPGKVKKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVVADDLVLLGEEK
  
Inhibitor
Name:
BDBM50179896
Synonyms:
2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole | CHEMBL377727
Type:
Small organic molecule
Emp. Form.:
C13H9Cl2F3N2
Mol. Mass.:
321.125
SMILES:
FC(F)(F)c1cc(Cl)c(c(Cl)c1)-n1cc2CCCc2n1
Structure:
Search PDB for entries with ligand similarity: