Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50182766
Substrate
n/a
Meas. Tech.
ChEMBL_351511 (CHEMBL870070)
IC50
>33000±n/a nM
Citation
 Gopalsamy, A; Shi, M; Ciszewski, G; Park, K; Ellingboe, JW; Orlowski, M; Feld, B; Howe, AY Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase. Bioorg Med Chem Lett 16:2532-4 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50182766
Synonyms:
2-(7,8-difluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL205353
Type:
Small organic molecule
Emp. Form.:
C17H19F2NO2
Mol. Mass.:
307.3351
SMILES:
CCCC1(CC(O)=O)CCCc2c1[nH]c1c(F)c(F)ccc21
Structure:
Search PDB for entries with ligand similarity: