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Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50239015
Substrate
n/a
Meas. Tech.
ChEMBL_2245809 (CHEMBL5160019)
Kd
13±n/a nM
Citation
 Liang, Q; Zuo, H; Yang, T; Yin, J; Huang, X; Wang, J; Li, Q; Yin, G; Zhao, X Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library. Eur J Med Chem 233:0 (2022) [PubMed] 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM50239015
Synonyms:
CHEBI:6993 | MK-476 | Montelukast Sodium | Singulair
Type:
Small organic molecule
Emp. Form.:
C35H35ClNNaO3S
Mol. Mass.:
608.165
SMILES:
[Na+].CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC([O-])=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 |r|
Structure:
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