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Target
Elongin-C
Ligand
BDBM50604004
Substrate
n/a
Meas. Tech.
ChEMBL_2245961 (CHEMBL5160171)
Kd
56±n/a nM
Citation
 Zhou, C; Fan, Z; Zhou, Z; Li, Y; Cui, R; Liu, C; Zhou, G; Diao, X; Jiang, H; Zheng, M; Zhang, S; Xu, T Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem 65:3923-3942 (2022) [PubMed] 
Target
Name:
Elongin-C
Synonyms:
ELOC | ELOC_HUMAN | Elongin 15 kDa subunit | Elongin-C | RNA polymerase II transcription factor SIII subunit C | SIII p15 | TCEB1 | Transcription elongation factor B polypeptide 1
Type:
PROTEIN
Mol. Mass.:
12466.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108414
Residue:
112
Sequence:
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
  
Inhibitor
Name:
BDBM50604004
Synonyms:
CHEMBL5205396
Type:
Small organic molecule
Emp. Form.:
C57H76ClFN10O4S
Mol. Mass.:
1051.794
SMILES:
C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCN1CCN(CC1)c1cc(Cl)cc2n(Cc3cc(C)c(F)c(C)c3)c(nc12)N1CC2(CNC2)C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
Structure:
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