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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50538503
Substrate
n/a
Meas. Tech.
ChEMBL_2246302 (CHEMBL5160512)
IC50
0.090000±n/a nM
Citation
 Li, D; Sloman, DL; Achab, A; Zhou, H; McGowan, MA; White, C; Gibeau, C; Zhang, H; Pu, Q; Bharathan, I; Hopkins, B; Liu, K; Ferguson, H; Fradera, X; Lesburg, CA; Martinot, TA; Qi, J; Song, ZJ; Yin, J; Zhang, H; Song, L; Wan, B; DAddio, S; Solban, N; Miller, JR; Zamlynny, B; Bass, A; Freeland, E; Ykoruk, B; Hilliard, C; Ferraro, J; Zhai, J; Knemeyer, I; Otte, KM; Vincent, S; Sciammetta, N; Pasternak, A; Bennett, DJ; Han, Y Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J Med Chem 65:6001-6016 (2022) [PubMed] 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50538503
Synonyms:
CHEMBL4645108
Type:
Small organic molecule
Emp. Form.:
C23H18ClFN2O3
Mol. Mass.:
424.852
SMILES:
Fc1ccc(NC(=O)C2(COC2)c2ccc(NC(=O)c3cccc(Cl)c3)cc2)cc1
Structure:
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