Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50187033
Substrate
n/a
Meas. Tech.
ChEMBL_375684 (CHEMBL863690)
IC50
>1000±n/a nM
Citation
Yang, L; Zhou, C; Guo, L; Morriello, G; Butora, G; Pasternak, A; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Ayala, JM; Goyal, S; Hanlon, WA; Cascieri, MA; Springer, MS Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists. Bioorg Med Chem Lett 16:3735-9 (2006) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
Inhibitor
Name:
BDBM50187033
Synonyms:
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piperidin-1-yl)ethylamino)-2-(thiophen-3-yl)acetamide | CHEMBL211775
Type:
Small organic molecule
Emp. Form.:
C22H25F6N3OS
Mol. Mass.:
493.509
SMILES:
FC(F)(F)c1cc(CNC(=O)[C@@H](NCCN2CCCCC2)c2ccsc2)cc(c1)C(F)(F)F