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Target
Serine/threonine-protein phosphatase 5
Ligand
BDBM50090505
Substrate
n/a
Meas. Tech.
ChEMBL_2268010
IC50
400±n/a nM
Citation
 Zhang, Q; Fan, Z; Zhang, L; You, Q; Wang, L Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer. J Med Chem 64:8916-8938 (2021) [PubMed] 
Target
Name:
Serine/threonine-protein phosphatase 5
Synonyms:
PP-T | PP5 | PPP5 | PPP5C | PPP5_HUMAN | PPT | Protein phosphatase 5 (PP5) | Protein phosphatase T | Serine/threonine-protein phosphatase 5
Type:
Enzyme
Mol. Mass.:
56875.49
Organism:
Homo sapiens (Human)
Description:
P53041
Residue:
499
Sequence:
MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM
  
Inhibitor
Name:
BDBM50090505
Synonyms:
(1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | (1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione | CANTHARIDIN | CHEMBL48449 | cid_6708701
Type:
Small organic molecule
Emp. Form.:
C10H12O4
Mol. Mass.:
196.1999
SMILES:
C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O
Structure:
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