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Target
Cyclin-dependent kinase 10
Ligand
BDBM50410826
Substrate
n/a
Meas. Tech.
ChEMBL_2268704
IC50
>10000±n/a nM
Citation
 Soltan, OM; Shoman, ME; Abdel-Aziz, SA; Narumi, A; Konno, H; Abdel-Aziz, M Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy. Eur J Med Chem 225:0 (2021) [PubMed] 
Target
Name:
Cyclin-dependent kinase 10
Synonyms:
2.7.11.22 | CDK10 | CDK10_HUMAN | Cell division protein kinase 10 | Cyclin-dependent kinase 10 | Serine/threonine-protein kinase PISSLRE
Type:
PROTEIN
Mol. Mass.:
41053.23
Organism:
Homo sapiens
Description:
ChEMBL_109746
Residue:
360
Sequence:
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
  
Inhibitor
Name:
BDBM50410826
Synonyms:
CHEMBL5285373
Type:
Small organic molecule
Emp. Form.:
C22H25N3O5S
Mol. Mass.:
443.516
SMILES:
COc1ccc(CCNc2nc(N)c(s2)C(=O)c2cc(OC)c(OC)c(OC)c2)cc1
Structure:
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