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Target
Histone deacetylase
Ligand
BDBM50195599
Substrate
n/a
Meas. Tech.
ChEMBL_416719 (CHEMBL909985)
IC50
60±n/a nM
Citation
 Mai, A; Massa, S; Rotili, D; Simeoni, S; Ragno, R; Botta, G; Nebbioso, A; Miceli, M; Altucci, L; Brosch, G Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J Med Chem 49:6046-56 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
Histone deacetylase HD1B
Type:
PROTEIN
Mol. Mass.:
50930.01
Organism:
Zea mays
Description:
ChEMBL_422128
Residue:
458
Sequence:
MAASGEGVSLPSPAGGEDAHRRRVSYFYEPSIGDYYYGQGHPMKPHRIRMAHSLVVHYGLHRLLELSRPYPASEADIRRFHSDDYVAFLASATGNPGVLDPRAIKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKFHRRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVPLSDGIDDTTFRGLFQCIIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRFLRSYNVPMMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNDYYEYFGPDYTLHIQPKSVENLNTTKDLENIKNMILENLSKIEHVPSTQFHDRPSDPEAPEEKEEDMDKRPPQRSRLWSGGAYDSDTEDPDSLKSEGKDVTANFQMKDEPKDDL
  
Inhibitor
Name:
BDBM50195599
Synonyms:
CHEMBL214877 | N-hydroxy-3-(3,4-dihydro-4-oxo-6-phenethyl-2-pyrimidinylthio)propanamide
Type:
Small organic molecule
Emp. Form.:
C15H17N3O3S
Mol. Mass.:
319.379
SMILES:
ONC(=O)CCSc1nc(CCc2ccccc2)cc(=O)[nH]1
Structure:
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