Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50196248
Substrate
n/a
Meas. Tech.
ChEMBL_418542 (CHEMBL913510)
EC50
4630±n/a nM
Citation
 Mahindroo, N; Peng, YH; Lin, CH; Tan, UK; Prakash, E; Lien, TW; Lu, IL; Lee, HJ; Hsu, JT; Chen, X; Liao, CC; Lyu, PC; Chao, YS; Wu, SY; Hsieh, HP Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists. J Med Chem 49:6421-4 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50196248
Synonyms:
2-(1-(3-(6-benzoyl-1-propylnaphthalen-2-yloxy)propyl)-1H-indol-6-yloxy)-2-methylpropanoic acid | CHEMBL425254
Type:
Small organic molecule
Emp. Form.:
C35H35NO5
Mol. Mass.:
549.6561
SMILES:
CCCc1c(OCCCn2ccc3ccc(OC(C)(C)C(O)=O)cc23)ccc2cc(ccc12)C(=O)c1ccccc1
Structure:
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