Reaction Details Report a problem with these data
Target
Cholesterol 24-hydroxylase
Ligand
BDBM50609182
Substrate
n/a
Meas. Tech.
ChEMBL_2277110
IC50
2.7±n/a nM
Citation
Koike, T; Yoshikawa, M; Ando, HK; Farnaby, W; Nishi, T; Watanabe, E; Yano, J; Miyamoto, M; Kondo, S; Ishii, T; Kuroita, T Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J Med Chem 64:12228-12244 (2021) [PubMed]
More Info.:
Target
Name:
Cholesterol 24-hydroxylase
Synonyms:
CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H)
Type:
Protein
Mol. Mass.:
56834.45
Organism:
Homo sapiens (Human)
Description:
Q9Y6A2
Residue:
500
Sequence:
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC