Reaction Details Report a problem with these data
Target
Histidinol dehydrogenase
Ligand
BDBM50267976
Substrate
n/a
Meas. Tech.
ChEMBL_565320 (CHEMBL955161)
IC50
6±n/a nM
Citation
 Joseph, P; Abdo, MR; Boigegrain, RA; Montero, JL; Winum, JY; Köhler, S Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen. Antimicrob Agents Chemother 51:3752-5 (2007) [PubMed]  Article 
Target
Name:
Histidinol dehydrogenase
Synonyms:
HISX_BRUSU | hisD
Type:
PROTEIN
Mol. Mass.:
46060.70
Organism:
Brucella suis
Description:
ChEMBL_436509
Residue:
430
Sequence:
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNL
  
Inhibitor
Name:
BDBM50267976
Synonyms:
(S)-3-Amino-1-biphenyl-4-yl-4-(1H-imidazol-4-yl)-butan-2-one; dihydrochloride | (S)-3-amino-1-(biphenyl-4-yl)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride | CHEMBL483668
Type:
Small organic molecule
Emp. Form.:
C19H19N3O
Mol. Mass.:
305.3737
SMILES:
N[C@@H](Cc1cnc[nH]1)C(=O)Cc1ccc(cc1)-c1ccccc1 |r|
Structure:
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