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Target
Protection of telomeres protein 1
Ligand
BDBM50134030
Substrate
n/a
Meas. Tech.
ChEMBL_541324 (CHEMBL1027378)
IC50
63000±n/a nM
Citation
 Fu, YT; Keppler, BR; Soares, J; Jarstfer, MB BRACO19 analog dimers with improved inhibition of telomerase and hPot 1. Bioorg Med Chem 17:2030-7 (2009) [PubMed]  Article 
Target
Name:
Protection of telomeres protein 1
Synonyms:
POT1 | POTE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71443.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_541324
Residue:
634
Sequence:
MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTANQHSDVICQSEPDDSFPSSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKGRKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDLSAPFLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVMTFTLDDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI
  
Inhibitor
Name:
BDBM50134030
Synonyms:
9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido) acridine | CHEMBL336434 | N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide)
Type:
Small organic molecule
Emp. Form.:
C35H43N7O2
Mol. Mass.:
593.7616
SMILES:
CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Structure:
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